Week 1 of the 2026 NFL preseason has a three-game Friday slate, with all contests starting at 7 p.m. Each of the three features AFC teams facing NFC teams. Falcons (+5.5) and Dolphins vs.
Commanders (+2.5) are matchups we've previously seen in the Super Bowl, while the third contest is Jets vs. The latest NFL odds have New York favored by 6 points as Baker Mayfield won't take the field for Tampa, while the Jets are expected to play their starters. Bet NFL games at DraftKings.
Claim their new user offer here: If recent NFL preseason results matter to you, then the Falcons vs. Broncos game may stand out when making NFL bets. Denver is a perfect 6-0 in the preseason over the last two years, while Atlanta is winless (0-6) over that same span.
All of the updated Week 1 NFL preseason lines are listed below, and SportsLine's Larry Hartstein has locked in his best NFL picks for Friday's action. Visit our DraftKings promo code review to see their latest offers and get started. A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus.
He finished the 2025 season on a 50-37-1 run (57.5%). Anybody following his NFL betting picks at sportsbooks and on betting sites could have seen strong returns. Now, Hartstein has turned his attention to the latest Week 1 NFL preseason and NFL betting lines and locked in betting picks for every NFL matchup on Friday.
Head here to see his picks. Visit our Kalshi promo code review to see their latest offers and get started. Claim the Kalshi signup offer here now: One of Hartstein's strongest Week 1 NFL picks for Friday is the Jets (-6) at home versus the Bucs.
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