A four-game schedule kicks off Week 3 of the 2026 NFL preseason on Thursday. The Steelers at Bills kick things off at 7 p.m. ET, followed by Patriots at Browns and 49ers at Raiders at 8 p.m.
The last game of the night will feature the Rams at the Chargers at 10 p.m. The latest NFL odds for preseason action on Thursday list the Patriots at -2.5 on the road and Raiders at -2.5 at home. The Bills are -3 home favorites.
Bet NFL games at DraftKings. Claim their new user offer here: The largest line of the night is Chargers -4.5 over the Rams, who will be playing few if any starters. Before making any Week 3 NFL preseason picks All of the updated Week 3 NFL preseason lines are listed below, and SportsLine's Larry Hartstein has locked in his best NFL picks for Thursday's action.
Visit our DraftKings promo code review to see their latest offers and get started. A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. He finished the 2025 season on a 50-37-1 run (57.5%).
Anybody following his NFL betting picks at sportsbooks and on betting sites could have seen strong returns. Now, Hartstein has turned his attention to the latest Week 3 NFL preseason and NFL betting lines and locked in betting picks for every NFL matchup on Friday. Head here to see his picks.
Visit our Kalshi promo code review to see their latest offers and get started. Claim the Kalshi signup offer here now: One of Hartstein's strongest Week 3 NFL picks for Thursday is the Rams (+4.5) on the road versus the Chargers. Although the Rams aren't expected to play any of their starters, they have seen exceptional quarterback play this preseason from both Ty Simpson and Stetson Bennett IV.
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