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2026 NFL Week 2 early odds: Bills favored over Lions as Buffalo opens new stadium, Eagles road favorites

2026 NFL Week 2 early odds: Bills favored over Lions as Buffalo opens new stadium, Eagles road favorites

cbssports.com 14.09.2026 13:17 3 views
Here's a look at the lines for Week 2 in the NFL as we continue the start of the 2026 season

If you wanted points, look no further than Bears-Panthers, who combined for 96 in their opening clash. Namely, the Cardinals pulling off the outright win over the Chargers on the road, while the Jets went down to Tennessee and beat the Titans. Anything you wanted, Week 1 probably had you covered.

Now, the train keeps moving as we eye Week 2. The Week 2 slate is just as juicy as Week 1 by the looks of it. We get things started with the Lions and Bills squaring off on Thursday night from Buffalo's brand-new Highmark Stadium.

Then, we have five divisional matchups on the Sunday slate along with a few tantalizing conference bouts, including Bengals-Texans and Jaguars-Broncos. As we begin our prep for Week 2, let's take our first look at the betting odds to see who the oddsmakers have coming out on top and what shootouts could occur across the league. All lines via DraftKings; all games on Sunday unless noted Buffalo opens up the new Highmark Stadium on Thursday night when they play host to the Detroit Lions.

The line has stood firm at Bills -3, but points are expected to come in bunches in this matchup. The total has jumped to 53.5, up from 51.5 at the open. Both of these teams have high-powered offenses, so it's not surprising to see this number creeping into the mid-50s.

Not only did each offense drop 30 or more points in Week 1, but so did each of their defenses. Last season, the Bills were just 4-5 ATS at home, so they'll hope that their new digs will be a bit more favorable. Atlanta is a slim 1.5-point favorite over Carolina even as its quarterback situation remains in flux.

Cooper Rush got the start against Pittsburgh in the open, but whether or not he sees the field in Week 2 will depend on the health of either Tua Tagovailoa or Michael Penix Jr. They were each sidelined for Week 1 due to injury, and their status will be worth monitoring all week. Meanwhile, Carolina did hang with Chicago for a while, but its defense was a calamity, allowing 59 points.

Extract — continue reading at the source.

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