The Week 0 college football schedule kicks off with several mouthwatering matchups, including UNC vs. NC State has dominated its rivalry with Virginia in recent years, winning six of the past seven meetings, which includes a thrilling 35-31 victory in 2025. Despite that recent success, NC State is a four-point underdog against the Cavaliers, according to the latest college football odds at some of the top betting sites like DraftKings Sportsbook.
SportsLine's model is backing Virginia to cover the spread in 53% of simulations on Saturday, projecting a 30-24 victory for the Cavaliers. Claim the latest DraftKings promo code, where new users get $200 in bonus bets after making a $5 wager: The model is also backing Hawaii (+4) to cover the spread against Stanford, while the Over (56.5) hits 62% of the time in Memphis vs. Other notable Week 0 college football lines include UNC vs.
TCU (-8.5), San Jose St. vs. USC (-38.5) and New Mexico State vs. Before locking in your Week 0 college football picks, be sure to check out the top college football betting picks from SportsLine's advanced computer model.
Bet on college football with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets: The model simulates every FBS game 10,000 times. It is on a 31-19 run on top-rated college football money-line picks since the 2024 season. It has also been upgraded for the 2026 season to even better factor in the transfer portal to help nail college football betting picks at sportsbooks and on betting sites.
Claim $365 in bonus bets with a $10 bet by signing up for bet365 Sportsbook here: Combining the model's three picks into a Week 0 college football parlay would result in a payout of +585 (risk $100 to win $585). Bet it now at FanDuel Sportsbook and get $350 in bonus bets: Virginia is coming off a dominant season in which the Cavaliers won 11 games, which culminated with a 13-7 win over the Missouri Tigers in the TaxSlayer Gator Bowl. However, Virginia has struggled against the Wolfpack, losing four straight and six of the past seven meetings overall.
Despite that, Virginia will enter Saturday's contest full of confidence, having won eight of its last nine season openers. In addition, the Cavaliers are 5-0 against the spread in their last five games played in August. The SportsLine Projection Model is calling for Virginia to secure a 30-24 victory at home, helping the Cavaliers cover the spread in 53% of simulations.
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