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2026 Week 1 college football picks, predictions: Wisconsin-Notre Dame, Ole Miss-Louisville best bets

2026 Week 1 college football picks, predictions: Wisconsin-Notre Dame, Ole Miss-Louisville best bets

cbssports.com 06.09.2026 21:29 2 views
SportsLine's model reveals its Week 1 college football picks and best bets for Sunday, September 6

College football fans will be treated to three more games on Sunday, including No. 17 Washington vs. Washington State, No. 9 Ole Miss vs. No. 24 Louisville and No. 4 Notre Dame vs.

The Fighting Irish defeated Wisconsin 41-13 at Soldier Field in 2021, and now the two teams are set to square off at Lambeau Field on Sunday at 7:30 p.m. Notre Dame is a 20.5-point favorite against Wisconsin, according to the latest college football odds at some of the top betting sites like DraftKings Sportsbook. The over/under for Wisconsin vs.

Notre Dame is 46.5 points, unchanged from the opening line. SportsLine's model is backing Notre Dame to cover the spread in 65% of simulations, projecting a comfortable 39-12 victory for the Fighting Irish. Claim the latest DraftKings promo code, where new users get $200 in bonus bets after making a $5 wager: The model is also backing Washington State (+23.5) to cover the spread against Washington in the Apple Cup, while the Under (54.5) hits 60% of the time in Ole Miss vs.

Before locking in your Week 1 college football picks on Sunday, be sure to check out the top college football betting picks from SportsLine's advanced computer model. Bet on college football with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets: The model simulates every FBS game 10,000 times. It is on a 32-19 run on top-rated college football money-line picks since the 2024 season.

It has also been upgraded for the 2026 season to even better factor in the transfer portal to help nail college football betting picks at sportsbooks and on betting sites. Claim $365 in bonus bets with a $10 bet by signing up for bet365 Sportsbook here: Combining the model's three picks into a Week 1 college football parlay would result in a payout of +585 (risk $100 to win $585). Bet it now at FanDuel Sportsbook and get up to $350 in bonus bets: A heated in-state rivalry is set to renew on Sunday when Washington battles Washington State in the Apple Cup at 4 p.m ET.

The Huskies have dominated this series in recent years, winning eight of the last 10 meetings against Washington State. However, the Cougars have covered the spread in seven of the last 10 meetings overall. In addition, Washington State is 6-0 against the spread in its past six games as an underdog.

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