The NFL season is underway with all 32 teams in action in Week 1. The Rams and 49ers meet on Thursday night in the first ever NFL Australia game. Then the bulk of the Week 1 NFL schedule takes place on Sunday, finishing off with Cowboys vs.
Giants (+3) on Sunday night. Visit our Kalshi promo code review to see their latest offers and get started. Claim the Kalshi promo code CBSSPORTS here now and get a $25 bonus after $25 in trades: There are a number of solid matchups on Kickoff Weekend, including Bills vs.
Panthers (+3), Saints vs. Vikings (-1.5) and Commanders vs. The Chiefs (-2.5) face the Broncos on 'Monday Night Football' as quarterbacks Patrick Mahomes and Bo Nix will return from injuries.
Before locking in any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024.
Anybody following its picks at NFL betting sites could have seen strong returns. Now, the model has scoured the Week 1 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of nearly 25-1.
You can only see the model's Week 1 NFL picks at SportsLine. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: After simulating every game 10,000 times, the model likes the Over 48.5 combined points at betting apps in Cowboys vs. Giants to hit more than 60% of the time on Sunday at 8:20 p.m.
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