One of the toughest Week 2 NFL picks to successfully pull off is hitting on a Week 2 NFL score prediction. However, observing matchup history can certainly help, such as is the case with Sunday's Panthers vs. Carolina scored exactly 30 points in both matchups last season, as the Panthers have scored either 30 or 31 points in five of their last 17 games overall.
Of course, getting one team's point total is just half the battle in making the most of these NFL best bets. Visit our Polymarket promo code review and get a $50 sign-up bonus as a new user after a $10 deposit here: Carolina is a 1.5-point road favorite for Sunday's game, which has an over/under of 43.5. It's one of five divisional matchups to make Week 2 NFL bets on, alongside Bears vs.
Vikings (+5.5, 48.5), Chargers vs. Raiders (+7, 43.5), Cowboys vs. Commanders (+3.5, 50.5) and Seahawks vs.
Utilizing both the spread and total could also assist in nailing an NFL exact score, which could result in a monstrous return exceeding 100-1. Before making any Week 2 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen. A SportsLine expert and host, Cohen is evaluating the entire Week 2 NFL slate and delivers score predictions and logic for each matchup.
He finished the 2025-26 season with a 188-96-1 straight-up record (66%) with his picks at NFL betting sites and is 10-6 (63%) on his 2026 NFL picks. Anyone who followed Cohen's NFL predictions on betting sites could have seen strong returns. Now, Cohen has analyzed the latest NFL odds and made his Week 2 NFL picks.
You can only see Cohen's Week 2 NFL exact score predictions at SportsLine. Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS: After diving into all 16 games from the NFL Week 2 schedule, Cohen recommends backing the Cowboys (-3.5, 50.5) to defeat Washington at the best betting apps. The Cowboys are 13-2 against Washington with Dak Prescott under center, with the last four of those averaging 55.5 total points.
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