The New England Patriots find themselves in an urgent situation when they battle the Buffalo Bills in a key AFC East matchup to highlight the NFL Week 4 schedule. New England has started the season 1-2 and is coming off a 35-6 loss at Jacksonville on Sunday. Buffalo, meanwhile, moved to 3-0 with a 24-16 win over the Los Angeles Chargers.
The Bills enter as the -6.5 home favorites as Josh Allen looks to improve to 9-7 against New England all-time during the regular season. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: There are a number of intriguing matchups in Week 4, including Colts vs. Commanders (+3), Cowboys vs.
Eagles (+1.5), Broncos vs. 49ers (-3) and Lions vs. Panthers (+3.5) on 'Sunday Night Football.' 'Monday Night Football' features Falcons vs. Before locking in any Week 4 NFL picks, be sure to see the NFL parlay and betting advice from SportsLine's proven computer model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 4 of the 2026 NFL season on a 54-43 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns.
Now, the model has scoured the Week 4 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of nearly 25-1. You can only see the model's Week 4 NFL picks at SportsLine.
Visit our Kalshi promo code review to see their latest offers and get started. Claim the Kalshi promo code CBSSPORTS55 here now and get a $55 bonus after $25 in trades: After simulating every game 10,000 times, the model like the Vikings (-10), who cover the spread in well over 60% of simulations at betting apps against the Dolphins on Sunday at 4:05 p.m. The Vikings have won each of the last two meetings with the Dolphins, and five of the last eight.
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