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49ers vs. Broncos prediction: MVP favorite Brock Purdy and San Francisco look to stay undef

49ers vs. Broncos prediction: MVP favorite Brock Purdy and San Francisco look to stay undef

cbssports.com 03.10.2026 17:48 5 views
What you need to know ahead of these teams facing off on Sunday

The Denver Broncos and San Francisco 49ers are facing off on CBS this Sunday at 4:25 p.m. Both teams are coming off wins, with Denver at 2-1, while the 49ers are one of the two undefeated NFC teams at 3-0. The 49ers started the season strong, defeating the Rams, who were a Super Bowl favorite heading into the season.

They then defeated the Miami Dolphins and, most recently, took down the Arizona Cardinals. Denver began the year with a 31-10 divisional loss to the Kansas City Chiefs, then beat the Jacksonville Jaguars and the Los Angeles Rams. The Niners have been hit hard by injuries, which we'll get into more below, but they've shown they can adapt and win with whoever is on the field.

Their offense is a fun one to watch — remember the hook-and-ladder that allowed for Deebo Samuel to have a stat line of 0 receptions for 80 yards and a touchdown? The Broncos have demonstrated that they can come from behind and win, as they did last week against the Rams. Date: Sunday, Oct. 4 | Time: 4:25 p.m.

ETLocation: Levi's Stadium (Santa Clara, CA)TV: CBS | Stream: Paramount+Follow: CBS Sports AppOdds: 49ers -3 (via DraftKings) To say the Niners have been hit hard by injuries is an understatement. Wide receivers Ricky Pearsall, Demarcus Robinson, Christian Kirk and De'Zhaun Stribling; tight end Jake Tonges; running back Isaac Guerendo; offensive linemen Austen Pleasants and Brett Toth; defensive ends Sam Okuayinonu, Mikail Kamara and Andrew Farmer II; defensive tackles Alfred Collins and CJ West; linebacker Nick Martin; defensive back Darrick Forrest and cornerback Nate Hobbs, to name a few, have all been on the injured reserve or PUP list. There are so many players injured that the team has to strategically pick who they put on injured reserve so they don't run out of space, and that brings us to this week's injury report.

They had 10 players on Wednesday's report, including Mykel Williams, who began the season on the PUP list. Defensive lineman Nick Bosa was listed with a knee/calf injury and is expected to miss multiple weeks. He is not on IR likely because the team doesn't have the space.

Wide receivers Mike Evans (ribs) and KhaDarel Hodge (knee); linebacker Dre Greenlaw (quad); and defensive linemen James Thompson Jr. (ankle) and Keion White (hamstring) were all listed as non-participants in Wednesday and Thursday's practice. Running back Christian McCaffrey and tackle Trent Williams also did not practice on Wednesday, but were listed as "not injury related/resting player," and both returned as limited participants on Thursday. MVPurdy: Let's pretend it's not too soon to start talking about who the MVP will be and instead talk about why the 49ers quarterback is off to an MVP start.

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