The unbeaten San Francisco 49ers head north to Seattle on Sunday to face the Seattle Seahawks in an NFC West showdown. Brock Purdy has steered the Niners to a 4-0 start, but the defense has been just as noteworthy, ranking seventh in yards allowed. Sam Darnold and the Seahawks (3-1) get the 12th Man and a defense that ranks No. 1 in yards allowed.
That Seahawks defense allowed just nine points in a sweep of the 49ers last season, en route to a Super Bowl championship. This will be a challenge for that unit versus Purdy, who has accounted for 12 touchdowns and just one interception. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is set for 4:25 p.m.
ET from Lumen Field in Seattle. Seahawks odds have Seattle as a 3-point favorite. The over/under for total points scored is 45.5.
Before making any Seahawks vs. 49ers picks or 2026 NFL Week 5 predictions or 2026 NFL Week 5 predictions, be sure to see what the SportsLine projection model has to say. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024.
Anybody following its picks at NFL betting sites could have seen strong returns. Now, the model has zoned in on 49ers vs. You can head to SportsLine now to see its picks.
Here are several NFL odds and betting lines for Seahawks vs. 49ers: Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: After 10,000 simulations of 49ers vs. Seahawks , the model is going Over 45.5 points at betting apps. These defenses rank Top 10, but the offenses have been just as effective.
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