These days, you can’t scroll, shop, or even walk down the street without hearing about peptides. And while they’re in everything from supplements to IVs, the best peptide serums stand apart for their ability to boost hydration, increase collagen and elastin, and deliver smoother, more youthful skin—with the evidence to back up many of their claims. Vogue’s Favorite Peptide Serums: Best Overall: SkinMedica TNS Advanced+ Serum, $295 Best for Dry Skin: Medik8 Liquid Peptides, $64 Best Affordable: The Ordinary Multi-Peptide + Copper Peptides 1% Serum, $32 Best for Deep Wrinkles: Dr.
Dennis Gross DermInfusions Fill + Repair Serum, $78 Best for Mature Skin: SkinCeuticals P-TIOX, $150 Best Multitasking: COSRX 6X Peptide Collagen Skin Booster, $25 Best for Sensitive Skin: Allies of Skin Copper Tripeptide & Ectoin Advanced Serum, $199 But even in skincare, these ingredients are enjoying newfound attention. They’re quickly approaching hyaluronic acid-territory—which itself has become a household name—in part due to their versatility. The various types of peptides can work differently: Some kickstart collagen production, others inhibit enzymes that break down collagen and elastin (preserving what your skin already has), and certain peptides can improve the penetration and function of other ingredients, such as that all-important hyaluronic acid. (“Hyaluronic acid helps give skin that immediate cushion; certain peptides aim to support the framework over time,” says Dr.
Gohara.) Being a team player is part of the reason peptides have found popularity—and why that’s unlikely to wane anytime soon. Moreover, depending on how they work in skin, peptide serums can offer a variety of benefits, such as lasting moisture, increased collagen production, and a reduction in pigment production. With that, scroll ahead for the best peptide serum for every skin concern and goal.
Best Overall: SkinMedica TNS Advanced+ Serum Why We Love It: “This was one of the first peptide serums to be actually effective,” says Carmen Castilla, MD, a board-certified dermatologist in New York, NY, who also likes that it works for all skin types. That combination “makes this a sophisticated, comprehensive option for the appearance of fine lines, uneven texture, and loss of firmness,” says Dr. Gohara, who considers it an investment for anyone who wants several concerns addressed in one serum.
All told, the formula yields results in as soon as two weeks, all while being gentle enough for twice-daily use. Editor’s Experience: It’s not only convenient that this one, compact bottle contains two powerhouse serums—it’s also fun. I get to feel like a chemist when I pump both serums onto the back of my hand and mix them up, morning and night.
While testing this derm-loved salve for the past couple of days, I’ve noticed just how hydrating and creamy it feels on application, and that it leaves my skin with a subtle glow. I’m curious to see how its growth-factor technology will kick in over time. —Jenny Berg, contributor Love It Leave It Pairs peptides with growth factors for amplified repair The dual-chamber pumps can get clogged Free of fragrance making it especially gentle Best for Dry Skin: Medik8 Liquid Peptides Why We Love It: When it comes to peptides, more is often more—as is the case with this peptide serum, which offers 10 different peptides to firm, plump, and smooth skin. They’re housed in a copper peptide that delivers them exactly where they’re most needed in the skin to provide results effectively and quickly (think weeks, not months).
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