The NFL returned in full force with an exciting Week 1 schedule -- at least when it came to the Sunday day games -- and the Week 2 action kicks off with an exciting matchup between the Bills and Lions in a game that has the makings of a shootout. This is the debut game for Buffalo's new stadium, and as such, there are plenty of expectations from Bills Mafia to put points on the board. The best betting apps have this game lined at a whopping 54.5, and it's juiced to the Over to boot.
Bet on Thursday Night Football at DraftKings, where new users get $200 in bonus bets after they spend $5+: When you look at these two teams, a massive NFL betting total makes a lot of sense for this matchup. We thought coming into the year the Lions would be an explosive offense with a questionable defense. The departure of Sean McDermott was potentially poised to make the Bills a similar team, with Joe Brady now free to open up the playbook or perhaps be forced to because the defense wouldn't hold up as well.
Get a $25 bonus after $25 in trades by claiming the latest Kalshi promo code CBSSPORTS here: Each side scored at least 31 points in Week 1, but each gave up 30 or more points. Both games were very tight, too, and both the Lions and Bills kicked off 2026 with wins. Under 54.5 is probably the "smart" play (historically, teams on short rest with monster totals don't get there), but you'd be hard-pressed to get in front of a potential freight train here.
Having said that, there might be an opportunity to jump on with the short rest factor and how these two teams approach game-planning. Wager on the NFL with the latest FanDuel promo code and get up to $350 in bonus bets: This number should tell us a lot. It's lined Under 28 (aka four touchdowns) and juiced to the Under despite that massive total for the full game.
It's entirely possible we get some kind of whacky second half that features big plays from Josh Allen and Jared Goff's various explosive weapons (Jahmyr Gibbs and Jameson Williams in particular can house a ball at any moment). But both of these teams, despite scoring a ton, generally prefer to run the football. We should see lots of cautiously-stacked boxes here and plenty of James Cook/Gibbs in the first half.
Lions coach Dan Campbell is a bit of a wild card with his fourth-down decision making, but I actually think it can play in our favor as it extends drives and melts more clock if he's able to pick them up on Buffalo's side of the field. In Week 1, we saw a total of eight first-quarter drives between these two teams and their opponents -- I think we could get a similar, slow-paced start to this one, considering the stakes, the prime-time factor and the short week. Vegas agrees: the first-quarter total is just 10.5 and it's -130 to the Under.
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