Josh Allen and the Buffalo Bills hope to build momentum after a big win, while Kirk Cousins and the Las Vegas Raiders aim to stop a downward trend when the AFC teams face off in a Week 6 matchup Sunday on CBS and Paramount+. The Bills arrive to Vegas on a short week after a 37-34 overtime win over the Rams on Monday night. They rank among the NFL's highest-scoring teams at 32.8 points per game, powered by Allen's dual-threat ability and a strong ground game led by James Cook (532 rushing yards, 5 TDs).
The Raiders, meanwhile, have dropped two straight after a 3-0 start, including a 45-17 blowout loss to the Patriots. This is the first meeting between the teams since 2023, a 38-10 Buffalo victory. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is set for 4:25 p.m.
ET from Allegiant Stadium in Las Vegas. Raiders odds have Buffalo as a 5.5-point favorite. The over/under for total points scored is 53.5.
Before making any Raiders vs. Bills picks, be sure to see the Bills vs. Raiders predictions from SportsLine's proven model.
The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 6 of the 2026 NFL season on a 57-46 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns.
Now, the model has zoned in on Bills vs. You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Raiders vs.
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