In a possible Super Bowl preview, the Buffalo Bills clash with the Los Angeles Rams on 'Monday Night Football.' Buffalo is coming off a 29-26 loss to the New England Patriots in Week 4, while Los Angeles defeated the Philadelphia Eagles 24-20. The Bills (3-1), who lead the AFC East, are 1-0 on the road this season. The Rams (2-2), who are third in the NFC West, are just 1-1 as the home team in 2026.
Aaron Donald (back) is set to return after missing the past two games. Moore (shoulder) is questionable for Buffalo. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is set for 8:15 p.m.
ET from SoFi Stadium in Inglewood, Calif. Rams odds have Los Angeles as a 3.5-point favorites. The over/under for total points scored is 54.5.
Before making any Rams vs. Bills picks, be sure to see the 'Monday Night Football' predictions from SportsLine's proven model. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception.
The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns. Now, the model has zoned in on Bills vs.
You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Rams vs. Bills: Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: After 10,000 simulations of Bills vs.
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