Cognitive deficits are a core feature of first-episode psychosis (FEP) and are closely linked to impaired functioning. Higher cognitive reserve (CR) is a protective factor, whereas early developmental factors, such as lower birth weight (BW), may be associated with poorer cognition. This longitudinal cohort study examined whether BW was associated with 1-year functioning through CR and cognition in 117 patients with nonaffective FEP; 162 healthy controls contributed cross-sectional BW and CR comparisons.
Serial mediation models tested verbal memory and working memory separately. BW did not differ between groups, but CR was lower in FEP (P
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