The Denver Broncos visit the Arizona Cardinals in an NFL Week 7 matchup on Sunday at State Farm Stadium in Glendale, Ariz. The Broncos (4-2) have won four of their past five games, including a 17-14 overtime victory against the reigning Super Bowl champion Seattle Seahawks on Thursday Night Football in Week 6. The Cardinals (2-4) were 12.5-point road underdogs against the Los Angeles Rams but came away with an 18-16 victory.
Sunday's kickoff is set for 4:05 p.m. The Broncos are 4.5-point road favorites in the latest Broncos vs. Cardinals odds at DraftKings Sportsbook, and the Over/Under is 42.5.
Target NFL predictions at Kalshi, where new users can get a $55 bonus with the best Kalshi promo code CBSSPORTS55: We'll break down the latest Broncos vs. Cardinals odds from DraftKings and deliver our best bets for the contest with help from the SportsLine Projection Model. The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on betting sites on top-rated NFL picks since its inception.
The model entered Week 7 of the 2026 NFL season on a 58-48 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns. The Broncos have been having problems on offense, with quarterback Bo Nix struggling and not throwing the ball downfield as much as expected.
Still, Denver's only losses have come against teams that remain unbeaten (49ers and Chiefs). Nix has 1,049 passing yards, averaging 174.8 per game, 5.6 per attempt and 9.2 per completion. He has thrown six TD passes and three interceptions.
Denver is averaging the second-fewest yards (252.2) and seventh-fewest points (19.0) per game in the NFL. Nix hasn't been getting a ton of help, with running backs J.K. Dobbins (270 rushing yards) and RJ Harvey (244 total yards) part of a rushing attack that's averaging just 3.4 yards per carry.
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