Cross-state rivals will meet in Week 2 of the 2026 NFL Preseason when the Los Angeles Chargers host the San Francisco 49ers on Thursday. These franchises have met 45 times in preseason history, with San Fran holding the 26-19 edge. Justin Herbert and Brock Purdy sat in Week 1 but are expected to see action on Thursday.
The Niners fell in the first exhibition game, 19-13 to Tennessee, while L.A., in a game started by former Niners top pick, QB Trey Lance, defeated Houston last week, 27-7. Visit our DraftKings promo code review to see their latest offers and get started. Claim the latest DraftKings signup promo now: Kickoff is at 10 p.m.
ET from SoFi Stadium in Inglewood, Calif. Chargers odds have San Francisco as 1.5-point favorites, while the over/under for total points scored is 38.5 via SportsLine consensus. Before making any Chargers vs. 49ers picks, be sure to see what Jeff Hochman has to say.
Hochman emerged on the sports betting scene in the 1990s. Today he's one of the nation's most respected and selective handicappers. He's 99-88-3 (+686) over the past five NFL seasons.
Anybody following his NFL betting picks at sportsbooks and on the best betting apps could have seen strong returns. Now, Hochman has zeroed in on 49ers vs. Chargers and locked in his best bets.
You can head to SportsLine now to see his picks. Here are several NFL odds and betting lines for Chargers vs. 49ers: Hochman has analyzed 49ers vs. Chargers and is leaning Under 39 combined points for over/under betting.
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