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Cholesterol may disrupt the brain’s cleaning system in Alzheimer’s disease

Cholesterol may disrupt the brain’s cleaning system in Alzheimer’s disease

newscientist.com 21.10.2026 21:00 7 views
The glymphatic system flushes toxins out of the brain, but this seems to be disrupted in Alzheimer's disease, and cholesterol may be involved

Check your subscription status, update your details and more. Cholesterol may disrupt the brain’s cleaning system in Alzheimer’s disease The glymphatic system flushes toxins out of the brain, but this seems to be disrupted in Alzheimer's disease, and cholesterol may be involved The glymphatic network seems particularly important for brain health The flow of fluid through the brain was drastically reduced in a mouse model of Alzheimer’s disease, and cholesterol may be responsible. Disruption to the glymphatic system, the brain’s waste-clearance network, contributes to the build-up of harmful proteins associated with the condition.

Now, cholesterol has been linked to a reduction of this circulation, perhaps by blocking crucial passages within the brain. However, this is far from established and many questions remain. Receive a weekly dose of discovery in your inbox.

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