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Christina Applegate Reveals She Was Misdiagnosed With MS: ‘I’m Back at Square One’ and It’s a ‘Mindf—’

Christina Applegate Reveals She Was Misdiagnosed With MS: ‘I’m Back at Square One’ and It’s a ‘Mindf—’

variety.com 20.10.2026 13:53 2 views
Christina Applegate returned to her podcast, “MeSsy,” on Tuesday with some shocking news: She was misdiagnosed with multiple sclerosis. After taking a break from the podcast for seven months due to her health, Applegate

Christina Applegate returned to her podcast, “MeSsy,” on Tuesday with some shocking news: She was misdiagnosed with multiple sclerosis. After taking a break from the podcast for seven months due to her health, Applegate tearfully shared the revelation in a two-part episode, saying that new technology led to the discovery. I haven’t gotten better … If anything, I’ve gotten worse in some ways,” she said.

Since then, she has become a fierce advocate for people with the disease — which causes damage to the central nervous system — and started the “MeSsy” podcast alongside “The Sopranos” star Jamie-Lynn Sigler as a way to share her experience and spread awareness. Despite learning she had been misdiagnosed, Applegate said that her symptoms remain and her illness has now become a mystery. Every single one,” she said.

She said that she’s still in a “state of shock,” adding: “It’s a mindfuck, for sure.” “It’s this weird feeling because I became this — you and I, the poster children for MS,” she said. I had a fucking reason as to why my day sucked every day. And now I don’t have a reason and it’s very unnerving and it’s really confusing for me.” In the second part of the podcast episode, Applegate got emotional thinking about the past five years, and how confused she is now.

I lost my job … It stopped my life,” she said. I can’t walk from the car to the room. Nothing magical happened when she said, ‘You don’t have MS.’ Nothing magical happened.” Listen to the full “MeSsy” episodes below.

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