While the 2026 college football season got a hearty appetizer with Week 0, the main course will be served with the Week 1 college football schedule. There are 90 games involving FBS teams on the slate, with several intriguing non-conference matchups. Lane Kiffin makes his LSU debut versus Clemson on Saturday, which has his Tigers as 10.5-point favorites per the latest Week 1 college football odds.
Then on Sunday, the only ranked contest of the weekend occurs with Kiffin's former squad in No. 9 Ole Miss vs. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Other top non-conference games include UCLA vs. Cal (+1.5), which used to be a Pac-12 rivalry, as well as Baylor vs.
The No. 1 team in the land, Ohio State, is at -50.5 to target with Week 1 college football picks as the Buckeyes begin their campaign hosting Ball State. Before locking in any Week 1 college football picks, be sure to see the latest college football predictions from SportsLine's proven model. The model simulates every FBS game 10,000 times.
It is on a 32-19 run on top-rated CFB money-line picks since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns. Now, it has turned its attention to the latest college football odds for Week 1 and locked in picks for every FBS matchup.
Head here to see every pick. Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS: One of the top college football picks the model is recommending for Week 1: Auburn (-7.5, 58.5) covers against Baylor in a 3:30 p.m. No team performed worse versus the line than the Bears last year, going 2-10 ATS.
One of those defeats came to Auburn in Week 1, at home, and now Baylor has to travel, where it has lost its last three with a 17-point average margin of defeat. This Auburn team is better than last year's squad, courtesy of the addition of QB Byrum Brown. Last year at USF, he was the only quarterback in the nation with 3,000 passing and 1,000 rushing yards.
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