The Week 10 college football odds are filled with slim lines, which is appropriate given all of the intriguing ranked matchups. In just the SEC alone, there's Alabama vs. Ole Miss (+3.5) and Texas vs.
Missouri (+2.5) to make CFB picks on at college football betting sites. Elsewhere, we're blessed with a top-5 matchup as the No. 1 Miami Hurricanes visit No. 4 Notre Dame. The Fighting Irish are 5.5-point favorites as they look to avenge last year's loss to the Canes.
Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Out west, the next iteration of the Holy War will take place between BYU and Utah, as the Cougars seek a fourth straight win over the Utes. This series dates back over 100 years and has the third-ranked Utes favored by 5.5 points at home, according to the Week 10 college football spreads. Before locking in any Week 10 college football picks on these games or others, be sure to see the latest college football predictions from SportsLine's proven model.
The model simulates every FBS game 10,000 times. It entered Week 10 with an 80-77 record on all top-rated college football picks at betting sites this season. Now, it has turned its attention to the latest college football odds for Week 10 and locked in picks for every FBS matchup.
Head here to see every pick. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after $10 in trades: One of the top Week 10 college football picks the model is recommending for the best betting apps: Ohio State (-7, 48.5) covers versus Oregon in a 3:30 p.m. Ohio State is coming off a loss at USC, but freshman QB Luke Fahey should feel much more comfortable at home against a Ducks defense which has seen just three other Big Ten teams allow more passing touchdowns.
While Oregon is coming off a win over Northwestern, OU is just 1-3 ATS following a victory this season. The Buckeyes have covered in 80% of home games since the start of 2025 as they're projected to win by double-digits on Saturday, covering over 60% of the time. Another Week 10 prediction: Oklahoma (+6.5, 45.5) covers at Florida well over 50% of the time.
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