All eyes will be on Oxford, Miss., during the Week 3 college football schedule as Lane Kiffin returns to The Grove. His former team in No. 8 Ole Miss will host Kiffin's new squad in seventh-ranked LSU, as the Tigers are 3-point road favorites per the Week 3 college football odds. This is the lone top 10 matchup one can make college football bets on this week, and each of their last six meetings have been won by the home team.
Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: Elsewhere, there is an eclectic mix of games to target with Week 3 college football bets, including several schools beginning conference play such as No. 2 Georgia vs. Arkansas (+25) and No. 12 USC vs. There are also non-conference battles like No. 10 Alabama vs.
Florida State (+20.5) and No. 25 Virginia vs. West Virginia (+10), plus the early-season staple of powerhouse programs facing Group of 6 teams like the newly top-ranked Texas Longhorns 30-point favorites over UTSA. Before locking in any Week 3 college football picks, be sure to see the latest college football predictions from SportsLine's proven model.
The model simulates every FBS game 10,000 times. It is on a 33-21 run on top-rated CFB money-line picks on betting sites since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal. Anybody following its college football betting picks could have seen strong returns.
Now, it has turned its attention to the latest college football odds for Week 3 and locked in picks for every FBS matchup. Head here to see every pick. Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS: One of the top Week 3 college football picks the model is recommending for best betting apps: South Carolina (-3.5, 58.5) covers at home versus Mississippi State at 4:15 p.m.
ET in nearly 60% simulations. The Gamecocks have defeated the Bulldogs in eight of their last nine meetings as this is one of the SEC's most lopsided series over recent matchups. SC's LaNorris Sellers has shown off his dual abilities with 270 yards and 3 touchdowns through the air in Week 1, followed by 119 yards and a score on the ground last week.
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