Six ranked matchups highlight the Week 10 college football schedule, with a pair of top-10 matchups anchoring the slate. No. 7 BYU heads to No. 3 Utah, with the Utes listed at -5.5 in the latest Week 10 college football odds. Top-ranked Miami goes to Notre Dame with the Irish favored by 5.5 points in that one.
Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the best Kalshi promo code CBSSPORTS55: Other Week 10 college football lines of note include No. 2 Georgia at No. 12 Ole Miss (+3.5), No. 9 Alabama at No. 15 LSU (-5.5), No. 10 Texas at No. 19 Missouri (+2.5) and Oregon at No. 11 Ohio State (-7) in a Big Ten on CBS game on CBS and Paramount+. Before locking in any Week 10 college football picks on those games or others, be sure to see the latest college football score predictions from SportsLine's proven model. The model simulates every FBS game 10,000 times.
It enters Week 10 on an 80-77 run on all top-rated college football picks at betting sites. Now, it has turned its attention to the latest college football odds for Week 10 and locked in picks for every FBS matchup. Head here to see every pick.
Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after $10 in trades: One college football score prediction for the Week 10 college football schedule at the best betting apps and college football betting sites: The model is projecting Tennessee (-6.5) to beat Kentucky 27-19 in a 6:15 p.m. That makes the Vols the better value against the spread 53% of the time and the Under (50.5) the pick 62% of the time. Kentucky has been one of the biggest surprises in college football as the No. 8 Wildcats have surged to a 7-1 start (5-1 SEC) under first-year head coach Will Stein, tying them with Georgia atop the SEC standings.
This will be their toughest road test yet, however, as Neyland Stadium is one of the most difficult places to play in the nation. The Vols handled Alabama by 16 points in their last game at home. The Vols have covered at home in every SEC game thus far, and the model is projecting that trend to continue in this top-20 matchup on Saturday.
The Tennessee defense also holds strong again, keeping this game in the 40s and under the total. See the model's score predictions for every other matchup here. The model has revealed an exact score prediction for each Week 10 college football game.
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