The San Francisco 49ers will look to stay perfect on the year when they take on the Washington Commanders in a key NFC matchup on 'Monday Night Football.' San Francisco defeated Seattle 32-29 in Week 5, while Washington tied the New York Giants 27-27. The Commanders (1-3-1), who are fourth in the NFC East, are 0-2 on the road this season. The 49ers (5-0), who have outscored their opponents 154-93, are 3-0 on their home field in 2026.
San Francisco linebacker Dre Greenlaw has been suspended and will miss the game. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is set for 8:15 p.m. ET from Levi's Stadium in Santa Clara, Calif.
Commanders odds have San Francisco as 7.5-point favorites. The over/under for total points scored is 52.5. The 49ers lead the all-time series 23-12-1, winning three of the last four.
Before making any Commanders vs. 49ers picks, be sure to see the 'Monday Night Football' predictions' from SportsLine's proven model. The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 6 of the 2026 NFL season on a 57-46 run on top-rated picks dating back to 2024.
Anybody following its picks at NFL betting sites could have seen strong returns. Now, the model has zoned in on Commanders vs. 49ers. You can head to SportsLine now to see its picks.
Here are several NFL odds and betting lines for 49ers vs. Commanders: Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: After 10,000 simulations of Commanders vs. 49ers, the model is going Over 52.5 points at betting apps. The Over has hit in eight of Washington's last 10 games.
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