This study evaluates the comparative neuroprotective efficacy of a multi-component dietary pattern (the Mediterranean-DASH Intervention for Neurodegenerative Delay) versus a single-component elimination strategy (gluten-free diet) in an AlCl₃-induced rat model of Alzheimer’s disease. Sprague–Dawley rats were randomly divided into six groups (n = 6 each) and fed a balanced diet, the MIND diet, or a gluten-free diet, with or without AlCl₃ (100 mg/kg/day) administered orally for 8 weeks. AlCl₃ administration significantly elevated Aβ, total tau, and p-Tau S231 compared to non-induced controls (P
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