The Florida State Seminoles will look to make it three wins in a row when they take on the Louisville Cardinals in a key Atlantic Coast Conference matchup on Friday night. Florida State is coming off a 38-7 win over Virginia in Week 5, while Louisville dropped a 31-28 decision at North Carolina State. The Seminoles (3-2, 1-1 ACC), who have won two in a row, are 0-1 on the road this season.
The Cardinals (2-3, 1-2 ACC), who have dropped two consecutive games, are 2-1 on their home field in 2026. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is set for 7 p.m. ET at L&N Federal Credit Union Stadium in Louisville, Ky.
Florida State leads the all-time series 18-6, including two wins in a row. The Cardinals are 4-point favorites, with the over/under at 60.5 in the latest Florida State vs. The Cardinals are at -185 on the money line (risk $185 to win $100).
Both teams are 3-2 against the spread this season. Before making any Louisville vs. Florida State picks, check out the Florida State vs.
Louisville predictions from the SportsLine Projection Model. Louisville money line Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: After simulating Florida State vs. Louisville 10,000 times, SportsLine model is going Under 60.5 points at betting apps.
The Under has hit in three of the past five head-to-head meetings. It has also hit in eight of the past 10 Florida State games. The Under is 3-3 over the past six Louisville home games.
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