Florida State will look to shake off a sloppy Week 1 performance against New Mexico State as the Seminoles host No. 19 SMU in a standalone matchup on Labor Day Monday. FSU won 34-17 in Week 0, but wasn't close to covering as a 31-point favorite. Now the Seminoles take on the home underdog role against an SMU squad that has College Football Playoff aspirations after winning nine games last year and returning quarterback Kevin Jennings.
SMU beat FSU 42-16 in 2024 in SMU's first-ever ACC game and the only other time these teams have met. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Kickoff is set for 7:30 p.m. ET at Doak Campbell Stadium in Tallahassee, Fla.
The Mustangs are 2.5-point favorites in the latest SMU vs. Florida State odds, while the over/under is 54.5 points, up a point from the opening line. SMU is at -147 on the money line (risk $147 to win $100).
Before making any Florida State vs. SMU picks, check out the FSU vs. SMU predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is on a 33-20 run on top-rated CFB money-line picks on betting sites since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal. Anybody following its college football betting picks could have seen strong returns.
Now, the model has set its sights on FSU vs. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for SMU vs.
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