The 2026 MLB playoffs roll into the divisional round on Saturday with four Game 1s unfolding. The first one of the day is Cleveland Guardians vs. Chicago White Sox as the White Sox enter the 2026 ALDS off a sweep of the Astros in the wild-card round, while the second-seeded Guardians had a bye.
Lefty Parker Messick (12-9, 2.56 ERA) is the projected starter for Cleveland, while the White Sox will open with lefty Hagen Smith (3-3, 1.29 ERA. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after $10 deposit: First pitch from Progressive Field in Cleveland is at 1 p.m. Cleveland is the -149 favorite (risk $149 to win $100) in the latest Guardians vs.
White Sox odds, while the over/under is 7 runs. Before making any Guardians vs. White Sox picks, be sure to see the Braves vs.
Phillies predictions and betting advice from SportsLine's proven computer model. The SportsLine Projection Model simulates every MLB game 10,000 times and enters the 2026 MLB playoffs on a 31-25 run on all top-rated MLB money-line picks at betting sites, returning more than $900 for $100 players. Anyone following its picks at MLB betting sites could have seen strong returns.
Now, the model has set its sights on White Sox vs. Guardians and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks.
Here are several MLB odds and betting lines for Guardians vs. White Sox: New to sports trading? Visit our Kalshi promo code review and get a $55 trading bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: After 10,000 simulations of Guardians vs.
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