The BYU Cougars aim to move to 5-0 on the year when they host the 3-2 Iowa State Cyclones on Friday night. BYU went 12-2 last year but missed out on a College Football Playoff berth due to a pair of losses to Texas Tech. With the Red Raiders looking more vulnerable, the Cougars may be the team to beat in the Big 12.
The Cyclones are in a new era with former South Dakota State and Washington State head coach Jimmy Rogers taking over for Matt Campbell, who left Ames for Penn State after 10 seasons with the Cyclones. Rogers' squad is 3-2 with losses to Iowa and Utah. Kickoff is set for 10:15 p.m.
ET in Provo, Utah, and BYU is a 10.5-point favorite per the latest Iowa State vs. BYU in Week 6 at DraftKings and get $150 in bonus bets when you spend $5+: The Cougars and Cyclones clashed in Ames last year, with BYU taking home a 41-27 shootout win. The Cougars return many of their star players from that matchup, namely quarterback Bear Bachmeier, who passed for 307 yards and two touchdowns and rushed for 49 and a score as well.
Here, we break down the latest Iowa State vs. BYU odds from DraftKings Sportsbook and highlight our best bet for the matchup using the SportsLine Projection Model. The model simulates every FBS game 10,000 times.
It enters Week 6 on a profitable 40-35 run on all top-rated college football picks at betting sites. Anybody following its picks on college football betting sites could have seen strong returns. BYU is on a mission this year after failing to make the CFP despite winning 12 total games in 2025.
The Cougars avoid Texas Tech in the regular season this year, but they have two massive matchups taking place over the next few weeks as they host Notre Dame next week and visit unbeaten Utah on Nov. 7. This matchup with the Cyclones is one BYU should win, but Iowa State has been tough to begin Rogers' tenure as head coach. The Cyclones' first loss was by three to rival Iowa, and they fell by two touchdowns to Utah two weeks ago.
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