You've waited months for this moment, and it's finally here: the first Sunday of the 2026 regular season. Sure, you've already dabbled in a couple of games with the Seahawks-Patriots and Rams-49ers playing during the week, but this is different. You're not getting off work; you don't have homework to do the next day.
All you have to do is sit on the couch and watch hours of football. It's one of the more beautiful things you can do in this life, so let's relish in the fact that we have an entire season to look forward to, and it truly gets moving right now. Of course, you live a hectic life, so when you do finally get to sit down and take in the NFL, you may not have the time to do the research to confidently wager on a few contests.
Well, we're here to help. Below, you can find our last-minute bets for every game remaining on the Week 1 slate, which includes a breakdown of five games we consider to be our best bets. All NFL odds courtesy of DraftKings Sportsbook.
Whenever you have a quarterback battle in training camp, you want to enter Week 1 with a firm decision and the confidence that the player selected can get the job done. Does anyone feel confident in Deshaun Watson's ability to keep the offense afloat? Watson didn't look particularly sharp this summer, but beat out Shedeur Sanders anyway, and now he'll face a Jaguars defense that really came on strong down the stretch in 2025, which helped them cover their final eight regular-season games, en route to a league-best 12-5 ATS record.
While Cleveland has a new coach in Todd Monken, the franchise has historically been terrible against the spread on the road over the last two seasons. In that time, they are 4-13 ATS, which ranks as the worst record in the NFL. I think Cleveland has some solid pieces on the defensive side of the ball, but Trevor Lawrence entering his second year under Liam Coen could make the Jacksonville offense even more high-powered than it was a year ago.
If they build up a lead and force Watson into a pass-heavy game script, Josh Hines-Allen and Travon Walker could feast. Projected score: Jaguars 30, Browns 17The pick: Jaguars -8.5 The Laremy Tunsil injury (torn triceps on Aug. 8) was a gut punch to the Commanders, who are hoping to rebound after a disappointing 2025 season that was marred by injury. It looms large in this matchup against Philadelphia, particularly if Jonathan Greenard (who has been dealing with the pec injury) is able to go.
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