The LSU Tigers and Clemson Tigers face off in a marquee Week 1 matchup Saturday night to begin their 2026 college football seasons. Lane Kiffin debuts as head coach of LSU, matching wits with four-time national championship-winning coach Dabo Swinney and Clemson, a rematch of a Week 1 matchup last year, won 17-10 by LSU. Each team is looking to bounce back from subpar 2025 seasons; LSU finished 3-5 in the SEC, Clemson was 4-4 in the ACC.
Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Kickoff is set for 7:30 ET from Tiger Stadium in Baton Rogue, La. Host LSU is favored by 10 points in the latest Clemson vs. LSU odds, while the over/under is 50.5.
Before making any LSU vs. Clemson picks, check out the Clemson vs. LSU predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is on a 32-19 run on top-rated CFB money-line picks on betting sites since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal. Anybody following its college football betting picks could have seen strong returns.
Now, the model has set its sights on Clemson vs. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for LSU vs.
Clemson: New to sports trading? Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS: After 10,000 simulations of LSU vs. Clemson, the SportsLine model is recommending going Under (50.5 points) on the total at the best betting apps.
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