Lane Kiffin returns to Oxford on Saturday night as his No. 7 LSU Tigers open SEC play against the No. 8 Ole Miss Rebels. LSU announced itself in Week 1 with a 51-10 demolition of Clemson. Ole Miss needed every point to slip past Louisville 41-38 in one of the season's best early games.
Emotions will be running high in a game full of importance for SEC, national championship and fan pride reasons. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: Kickoff is set for 7:30 p.m. ET at Vaught-Hemingway Stadium in Oxford, Miss.
The Tigers are at -3 in the latest LSU vs. The over/under for total points is 58.5. Before making any LSU vs.
Ole Miss picks, check out the LSU vs. Ole Miss predictions from the SportsLine Projection Model. The model simulates every FBS game 10,000 times.
It is on a 33-21 run on top-rated CFB money-line picks on betting sites since the 2024 season, and it has been upgraded for the 2026 season to better factor in the transfer portal. Anybody following its picks on college football betting sites could have seen strong returns. Now, the model has set its sights on LSU vs.
You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Ole Miss vs. LSU: New to sports trading?
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