Neurotrauma remains clinically challenging due to heterogeneous biology and evolving injury cascades. Traditional severity-based classifications fail to capture underlying molecular complexity. Neuromics combines genomic, transcriptomics, proteomic, metabolomic, lipidomics, EV-omics, and single-cell technologies into systems framework to enable endotype discovery and AI-driven stratification.
We address modelling challenges, promote agent-driven multi-paradigm methods that go beyond steady-state assumptions, and advocate for targeted therapeutics, repositioning neurotrauma care as predictive, mechanism-informed, and personalised clinical management. The authors thank the Director, INMAS, DRDO, for the approval of this review paper under accession no. No funding was received for this research.
Traumatic Brain Injury & Metabolomics Department, Institute of Nuclear Medicine and Allied Sciences (INMAS) DRDO, Delhi, India Sonam Deshwal, Riya Vishnoi & Poonam Rana The authors declare no competing interests. Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material.
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To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. Deshwal, S., Vishnoi, R. & Rana, P. Neuromics: biomarkers discovery to precision diagnostics in neurotrauma. npj Syst Biol Appl (2026). https://doi.org/10.1038/s41540-026-00792-2 DOI: https://doi.org/10.1038/s41540-026-00792-2
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