Week 2 of the 2026 NFL season begins on Thursday, Sept. 17, with Thursday Night Football featuring the Detroit Lions and Buffalo Bills. There were plenty of surprising results in Week 1, and even though bettors might be leaning towards conventional wisdom for Week 2, opportunities exist for making profitable wagers on underdogs. This is especially true in parlay betting, where you can combine multiple results into one bet slip for more favorable odds.
SportsLine expert Mike Tierney has looked over the Week 2 NFL schedule and built out two parlays for the slate, with one featuring favorites and the other locking in underdogs. Get a $25 bonus after $25 in trades by claiming the latest Kalshi promo code CBSSPORTS here: Tierney is a veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, and he has covered the NFL for decades and reported from seven Super Bowls. He is 320-271-16 in the NFL the past four seasons, returning $1,867 to $100 players.
That includes Mike going 130-101 ATS (56.3 percent) the past two seasons. Here are his best parlays for Week 2. Make NFL bets with the latest DraftKings promo code and get $200 in bonus bets when you spend $5+: The Eagles essentially wrote the game plan last week for Dallas.
On defense, the Cowboys need to apply pressure to quarterback Jayden Daniels, which he felt on half of his dropbacks. On offense, they should go for chunk plays, which the Commanders allowed in bunches. George Pickens and CeeDee Lamb are licking their chops.
I can't fathom the Cowboys sinking to 0-2. They should settle down after being thrown a loop by new Giants coach John Harbaugh. Call this segment "I Love L.A," beginning with the Chargers.
They are facing a rare sense of urgency this early in the schedule with a gauntlet of games upcoming. It was a nice win for Vegas last Sunday, but think grain-of-salt: The conquered side (Miami) is by consensus the league's worst. Budding star running back Ashton Jeanty runs into a stingy rush defense while recovering tight end Brock Bowers might need another week off.
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