The 2026 NFL season has finally arrived as bettors are scrambling to make their Week 1 NFL picks if they haven't already. While ATS predictions will get most of the attention for games like Bills vs. Vikings (-1.5) and Chiefs vs.
Broncos (+2.5), one shouldn't bypass making total picks as well. An NFL betting trend from last year's opening slate saw the Under go 12-4 as Week 1 NFL lines for both the spread and over/under should be observed. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Bengals vs.
Buccaneers (+3.5, 51.5) is the only game with an O/U above 50, while Jets vs. Titans (-1.5, 39.5) is the only with a total below 40. Many of the Week 1 NFL spreads also span the gamut, so having some NFL betting advice would help navigate the opening slate of the year.
Before locking in any Week 1 NFL picks or NFL prop bets, be sure to check out the Week 1 NFL best bets and predictions from SportsLine's red-hot Vegas experts. SportsLine has more than 40 hand-picked Vegas experts who excel in multiple spots on betting sites. The NFL, however, is a strength for the site as SportsLine currently has five total experts who are on NFL runs that have returned $800 or more for $100 players and two who have returned more than $1,500.
Anybody following their picks on NFL betting sites could have seen huge returns. Now, with the Week 1 NFL schedule quickly approaching, SportsLine's top NFL betting experts have already locking in their picks. Go to SportsLine to see them all now.
Doug specializes in props across multiple sports and is 69-47 (+1521) with his last 116 NFL player prop bets. One of his top NFL player props for Week 1 is Eagles QB Jalen Hurts going Over 6.5 carries (-124) versus Washington on Sunday at 4:25 p.m. "There's been a lot of talk about Jalen Hurts running more this season in new offensive coordinator Sean Mannion's offense.
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