Week 1 of the NFL season kicks on Wednesday, and brings arguably the most challenging slate for NFL survivor picks since there's no in-season data to analyze. There are also several divisional matchups between rivals, including 49ers vs. Rams (-3.5) in Australia, Packers vs.
Vikings (-1.5), Commanders vs. Eagles (-5.5), Cowboys vs. Giants (+3) on Sunday night and Broncos vs.
Chiefs (-2.5) on Monday night. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Meanwhile no game has a larger NFL spread to consider for Week 1 NFL knockout picks than Cardinals vs. Chargers (-9.5), though the Jaguars are now -8.5 vs. the Browns, so there are some intriguing options.
Are those the games to target in survivor pools, or should you save those teams for later weeks? Before making any Week 1 NFL survivor pool picks or NFL knockout pool picks, see which team the red-hot SportsLine Projection Model just went all-in on. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception.
The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns. Now, it has turned its attention to the Week 1 NFL schedule and locked in its Week 1 survivor pool pick.
You can only see who the model is backing this week at SportsLine. In Week 1 of the 2026 NFL season, the model is not confident in the Dallas Cowboys (-3), even though they are -156 favorites on the money line against the Giants at the best betting apps. The New York Giants went 4-13 last season and have since hired a new coaching staff, led by former Baltimore Ravens coach John Harbaugh.
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