Week 1 of the NFL season could be the most challenging for NFL survivor picks. Because none of the 32 teams have played yet, there is no in-season data to utilize. There are also several divisional matchups between rivals, including 49ers vs.
Vikings (-1.5), Commanders vs. Eagles (-4.5), Cowboys vs. Giants (+2.5) and Broncos vs.
Meanwhile no game has a larger NFL spread to consider for Week 1 NFL knockout picks than Cardinals vs. Chargers (-10.5), which is 3 points clear of any other game. Visit our DraftKings promo code review to see their latest offers and get started.
Claim the latest DraftKings new user promo and bet on NFL here: The Seattle Seahawks enter the season as the defending Super Bowl champions, while the Kansas City Chiefs look to rebound after missing the postseason for the first time in 10 years. Kansas City had reached the Super Bowl the previous three seasons, winning two titles, before falling to 6-11 in 2025. Before making any Week 1 NFL survivor pool picks or NFL knockout pool picks, see which team the red-hot SportsLine Projection Model just went all-in on.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting apps could have seen strong returns.
Now, it has turned its attention to the Week 1 NFL schedule and locked in its Week 1 survivor pool pick. You can only see who the model is backing this week at SportsLine. In Week 1 of the 2026 NFL season, we can tell you the model is shying away from the Dallas Cowboys (-2.5), even though they are coming off a 7-9-1 record in 2025 and are -143 favorite on the money line.
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