A Big Ten matchup in the Week 10 college football schedule has the No. 12 Ohio State Buckeyes hosting the No. 23 Oregon Ducks on CBS and Paramount+. The Buckeyes (6-2, 4-1 Big Ten) saw a five-game win streak come to an end at the hands of an unranked USC squad, 30-18, on Saturday. Meanwhile, the Ducks (5-3, 3-2 Big Ten) are coming off a 34-26 upset of then-No. 20 Northwestern in Week 9.
Both teams have seen their starting quarterbacks sidelined, with Julian Sayin (arm) out for Ohio State and Dante Moore (concussion) injured for Oregon. Ohio State receiver Brandon Inniss is listed as doubtful. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is at 3:30 p.m.
ET from Ohio Stadium in Columbus, Ohio. The Buckeyes are 7.5-point favorites in the latest Oregon vs. The over/under for total points is 45.5.
Before making any Ohio State vs. Oregon picks, check out the Oregon vs. Ohio State predictions from the SportsLine Projection Model.
Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: After simulating Oregon vs. Ohio State 10,000 times, SportsLine model is going Over 45.5 points at betting apps. Each of the last four meetings have been high-scoring affairs as they all eclipsed 60 combined points.
The total has been eclipsed in all four Buckeyes home games in 2026, as well as in two of three road games for the Ducks. Additionally, the Over sports a 5-1 record over Oregon's last six as an underdog. Despite both teams missing their starting QBs, their respective backups didn't hold back either offense a week ago.
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