After a shocking loss at home to Oklahoma State, the Oregon Ducks are in the need of a statement win. The 20th-ranked Ducks will have that opportunity when they head to L.A. to face the 12th-ranked USC Trojans in a prime-time college football showdown on Saturday. USC (4-0) got past Rutgers 42-35 in Week 1 to win its Big Ten opener, led by USC QB Jayden Maiava, who leads the Big Ten with 1,173 yards and 12 touchdowns.
This will be the the first Big Ten game for Oregon (2-1), which rebounded from a surprising 39-31 loss to Oklahoma State to rout Portland State 84-0. Oregon has won four straight in the series and is 9-0 in Big Ten road games under Dan Lanning. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: Kickoff is set for 7:30 p.m.
ET at Memorial Coliseum in Los Angeles. The Ducks are 3-point favorites in the latest Oregon vs. USC odds, down from -5.5 earlier in the week.
The over/under for total points is 61.5. Before making any Oregon vs. USC picks, check out the Oregon vs.
USC predictions from the SportsLine Projection Model. The model simulates every FBS game 10,000 times. It is off to a profitable 22-19 start on all top-rated college football picks at betting sites so far this season, and it has been upgraded for the 2026 season to better factor in the transfer portal.
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