The Detroit Lions will look to make it two wins in a row when they clash with the Carolina Panthers in a key NFC matchup on 'Sunday Night Football.' Detroit held off the New York Jets 31-24 in Week 3, while Carolina dropped a 21-18 decision to the Cleveland Browns. The Lions (2-1), who tied for third in the division at 9-8 in 2025, are 0-1 on the road this season. The Panthers (1-2), who won the NFC South with an 8-9 mark last year, are 0-1 on their home field in 2026.
Carolina receiver Jalen Coker (quad) is out, while Xavier Legette (knee) was just placed on IR. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: Kickoff is set for 8:20 p.m. ET from Bank of America Stadium in Charlotte, N.C.
The Panthers have won six straight home games versus Detroit, dating back to 2002. Panthers odds have Detroit as 3.5-point favorites. The over/under for total points scored is 52, marking a 3.5-point rise since first opening.
Before making any Lions vs. Panthers or 'Sunday Night Football' predictions, be sure to see what the SportsLine projection model has to say. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception.
The model entered Week 4 of the 2026 NFL season on a 54-43 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns. Now, the model has zoned in on Lions vs.
You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Panthers vs. Lions: New to sports trading?
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