This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility: Scientists have discovered a gene that determines whether Japanese snails develop shells that are left- or right-coiling—with implications for understanding the underlying handedness of our own bodies. The researchers from the University of Nottingham and Tohoku University studied wild Euhadra snails in Japan to understand what makes one snail a mirror image of another.
They found that the coiling direction, or chirality, of a snail shell is due to natural differences in a gene that makes a protein called myosin. Myosin helps cells move and change shape by working with other proteins to make the cell scaffold. The researchers believe that a few small changes in the myosin protein affect how cells twist—either clockwise or counterclockwise—in the earliest stages of development.
This sets the direction for the chiral development of the adult snail's shell and body organs. Their findings are published in Current Biology. "In ways that we don't fully understand, the chirality of the basic building blocks of life ends up making bodies that are themselves also handed, or chiral.
This is the foundation for our hearts being on the left-hand side of our bodies and snail shells that usually coil to the right. "But while the majority of snails have shells that are right-coiling, a good number are left-coiling and a few species have both coiling types. Until now, we had no idea how they do this.
It turns out that small changes in a myosin gene produce mirror-image snails, while still producing healthy, viable animals," said professor Angus Davison, lead author of the study. The finding is important because it helps understand the common factors by which diverse animals develop their left and right sides. It is also timely because scientists solving the mystery of how chirality comes about received a Nobel Prize last week.
Unlike snails, nearly all other animals show the same fixed asymmetry, with rare reversals of body organs often associated with problems during the development of the embryo. In comparison, the team found that the left- and right-coiling versions of the Japanese snail develop normally as embryos, without any evidence of disease or pathology. Both the left- and right-coiling versions are ancient, but the "lefty" version shows evidence for natural selection.
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