A rare Week 1 conference battle takes place on Labor Day as the No. 19 SMU Mustangs visit the Florida State Seminoles. The Noles (1-0) kicked off their season with a Week 0 victory over New Mexico State by a score of 34-17. FSU went 5-7 overall last season, including a 2-6 mark in the ACC.
The Mustangs (0-0) went 9-4 a year ago, with a 6-2 conference mark, as they finished 2025 ranked 12th in the nation. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Kickoff is at 7:30 p.m. ET from Doak Campbell Stadium in Tallahassee, Fla.
SMU won the only prior meeting, which came in 2024. The Mustangs are 2.5-point favorites in the latest SMU vs. Florida State odds, while the over/under is 54.5 points.
The Mustangs are at -147 on the money line. Before making any Florida State vs. SMU picks, check out the SMU vs.
FSU predictions from SportsLine expert Josh Nagel. Nagel is a Reno-based analyst and radio host who has worked in the sports handicapping industry for more than 20 years. SportsLine's assistant managing editor has covered the wagering industry on a variety of platforms and has won numerous sports handicapping contests with his college football betting picks.
Nagel is 8-3 (+485) over his last 11 picks involving SMU at betting sites. Now, Nagel has analyzed SMU vs. Florida State and revealed his best bets.
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