Teams that can score a lot of points clash when the Detroit Lions take on the Carolina Panthers in a key NFC showdown on 'Sunday Night Football.' Detroit outlasted the New York Jets 31-24 in Week 3, while Carolina fell short 21-18 against the Cleveland Browns. The Lions (2-1), who are averaging 31 points per game, are giving up 31.7 and are 0-1 on the road. The Panthers (1-2), who are averaging 29.7 points, have allowed 27.7 and are 0-1 on their home field.
Carolina will be without several players, including cornerback Jaycee Horn (quad). Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: Kickoff is at 8:20 p.m. ET from Bank of America Stadium in Charlotte, N.C.
Panthers odds have Detroit as a 3.5-point favorite, while the over/under for total points scored is 50.5. The Lions are 3-7 ATS over their past 10 games, while the Panthers are 5-5. Before making any Lions vs.
Panthers picks or 'Sunday Night Football' predictions be sure to see what Larry Hartstein has to say. A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. He is coming off a 2025 NFL season in which he went 50-37 ATS (57.5%), putting him at 643-555 ATS all time.
For NFL Office Pool players, Hartstein picked every game straight-up the past two seasons and nailed nearly 70 percent of those picks on NFL betting sites. He also enters this season on a 22-11-1 roll on his last 34 picks involving the Lions, returning $966 to $100 players. Anyone following his picks on betting sites could have seen huge returns.
Now, Hartstein has zeroed in on Lions vs. You can head to SportsLine now to see his picks. Here are several NFL odds and betting lines for Panthers vs.
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