The claustrum regulates reward processing, but its role in feeding remains unknown. We report that palatable food recruits claustral neurons and a claustrum-to-medial prefrontal cortex circuit whose activation reduces high-fat diet intake. These findings identify the claustrum as a key regulator of appetitive feeding, with potential implications for metabopsychiatric disorders.
This is a preview of subscription content, access via your institution Receive 13 print issues and online access We are sorry, but there is no personal subscription option available for your country. Prices may be subject to local taxes which are calculated during checkout Datasets are available from the corresponding author upon reasonable request. Fodoulian L, Boillat M, Moulinier M, Carleton A, Rodriguez I.
A spatial single-cell atlas of the claustro-insular region uncovers key regulators of neuronal identity and excitability. Nat Commun. 2025;16:7830. Article PubMed PubMed Central Google Scholar Chia Z, Augustine GJ, Silberberg G.
Synaptic Connectivity between the Cortex and Claustrum Is Organized into Functional Modules. Curr Biol. 2020;30:2777–.e4. Qadir H, Stewart BW, VanRyzin JW, Wu Q, Chen S, Seminowicz DA, et al.
The mouse claustrum synaptically connects cortical network motifs. Cell Rep. 2022;41:111860. Zhao Z, He Y, Liu Y, Feng Q, Kim HY, Fan Y, et al.
A midbrain-cortical circuit mediated by a claustrum neuronal ensemble orchestrates drug-paired context memory processing. J Clin Invest. 2026;136:e196944. Wu M, Lai M, Zhou Y, Cheng Y, Shi S, Wang F, et al.
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