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Week 1 NFL betting guide, props, spreads: Model, expert, parlay, DFS and season-long fantasy picks unveiled

Week 1 NFL betting guide, props, spreads: Model, expert, parlay, DFS and season-long fantasy picks unveiled

cbssports.com 09.09.2026 21:46 3 views
SportsLine's team of Vegas experts and its proven model and experts to get you ready for Week 1 NFL betting

The ultimate goal of any Week 1 NFL betting strategy is to win, and there are several quarterbacks who've done nothing but that versus their opening opponents. Dak Prescott has won 14 straight games he's started and finished versus the Giants, as Dallas (-3) is favored at New York, per the latest Week 1 NFL odds. Additionally, Patrick Mahomes owns a 13-2 record against the Broncos as the Chiefs are 2.5-point home favorites over Denver.

Utilizing those two QBs in NFL player props or in Week 1 Fantasy football lineups could be some sage NFL betting advice, and you could also wager on their respective teams in a Week 1 NFL parlay. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Cowboys vs. Broncos are among half a dozen contests with spreads of 3 points or fewer at NFL betting sites.

Browns (+8.5) and Chargers vs. Cardinals (+9.5) are the only three matchups with Week 1 NFL lines of at least a touchdown. If you are looking for NFL picks, NFL parlays, Fantasy football rankings or NFL DFS picks for Week 1, SportsLine has you covered with its proven model, Machine Learning Model and team of experts.

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SportsLine's model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model has built a five-team parlay for Week 1 that pays nearly 25-1, and one of the legs is taking Over 48.5 points in Giants vs. The model has the Over hitting in nearly 70% of simulations, and the rest of the five-team parlay can be found here.

Mike McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once.

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