The NFL never shies away from loading up the opening week with must-see matchups, and the Week 1 NFL schedule is no different. From divisional battles like Packers vs. Vikings (+1.5) and Cowboys vs.
Giants (+2.5) to Aaron Rodgers' last ride in Steelers vs. Falcons (+3), you have a bevy of intriguing options to place Week 1 NFL bets on. Raiders is a matchup that may not garner as much interest as the aforementioned, but it still carries intrigue for Week 1 NFL picks as the only opening game guaranteed to have two new starters under center.
Bet NFL games at DraftKings. Claim their new user offer here: Miami's Malik Willis is expected to duel with Kirk Cousins, while No. 1 pick Fernando Mendoza rides the pine to start the 2026 NFL season. Vegas is a 3.5-point favorite, per the latest Week 1 NFL odds, as it's one of a dozen games with an NFL spread under 4 points.
All of the updated Week 1 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 1 NFL picks now. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024.
Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns. Now, it has turned its attention to the latest Week 1 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup. Head here to see every pick.
We can tell you one of the model's strongest Week 1 NFL picks is that the Jaguars (-7.5, 40.5) cover at home versus Cleveland in a Sunday 1 p.m. The model has the Jags prevailing versus the spread well over 50% of the time, continuing the success they had last year with a league-best 12-5 ATS mark in the regular season. Jacksonville was even more proficient versus the line at home, covering in 78% of games, also the best record in the NFL, while Cleveland was 2-6 ATS on the road, which was the second-worst mark in the NFL.
Extract — continue reading at the source.
