The NFL never shies away from loading up the opening week with must-see matchups, and the Week 1 NFL schedule is no different. From divisional battles like the primetime matchups of Chiefs vs. Broncos (+2.5) and Cowboys vs.
Giants (+3) to Jeremiyah Love's Arizona debut in Cardinals vs. Chargers (-8.5), there are a bevy of intriguing options to place Week 1 NFL bets on. Raiders is a matchup that may not garner as much interest as the aforementioned, but it still carries intrigue for Week 1 NFL picks as the only opening game guaranteed to have two new starters under center.
The Raiders will be without star tight end Brock Bowers, who's sidelined with a knee injury. Visit our Kalshi promo code review to see their latest offers and get started. Claim the Kalshi signup offer here now: Miami's Malik Willis will duel with Kirk Cousins, as the veteran gets the starting nod over Fernando Mendoza.
Vegas, who went 7-10 ATS last year, is a 3-point favorite per the latest Week 1 NFL odds. All of the updated Week 1 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 1 NFL picks now. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception.
The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns. Now, it has turned its attention to the latest Week 1 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup.
Head here to see every pick. We can tell you one of the model's strongest Week 1 NFL picks for the best betting apps is that the Jaguars (-8.5, 39.5) cover at home versus Cleveland in a Sunday 1 p.m. The model has the Jags prevailing versus the spread well over 50% of the time, continuing the success they had last year with a league-best 12-5 ATS mark in the regular season.
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