Divisional contests often result in slim NFL spreads, and that's the case when looking at the Week 10 NFL schedule. Half of the 14 games are divisional battles such as Packers vs. Vikings (+3.5), Panthers vs.
Saints (+1.5) and Steelers vs. Bengals (-3.5) on Sunday night. Elsewhere, Munich, Germany will host Patriots vs.
Lions (-2.5), which is the last overseas game this season, while Las Vegas will host Raiders vs. The latest Week 10 NFL odds have Seattle as 3.5-point road favorites as it plays its first ever regular season game in Sin City. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Your Week 10 NFL picks don't have to be restricted to spread bets, as you could also wager on the highest total of the season.
Cowboys vs. 49ers (-3.5) has an over/under of 55.5 as Dallas' last three games have averaged 57.3 points. Not nearly as many fireworks are expected in Ravens vs. Chargers (+5.5), which has a total of 38.5.
All of the updated Week 10 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 10 NFL picks now. The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 10 of the 2026 NFL season on a 62-52 run on top-rated picks dating back to 2024.
Anybody following its picks at NFL betting sites could have seen strong returns. Now, it has turned its attention to the latest Week 10 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup. Head here to see every pick.
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