The San Francisco 49ers look to move to 8-1 on the season and 5-1 in the conference when they battle the Dallas Cowboys in a key NFC matchup on Sunday afternoon. The 49ers enter as 4.5-point favorites despite being bitten hard by the injury bug. Running back Christian McCaffrey (hamstring) and Demarcus Robinson (ankle) are both on the mend and are expected to play.
In another key game involving NFC West teams, the Rams take on the Cardinals (+7.5) as Los Angeles looks to stay in the hunt for the division crown. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: There are a number of other intriguing matchups in Week 10, including several divisional matchups. Among them include Bills vs.
Saints (-1.5), Jaguars vs. Titans (+10), Vikings vs. Packers (-3.5) and Steelers vs.
Bengals (-3.5) on 'Sunday Night Football.' The Chargers are seeking to end an 11-game losing streak dating back to last season when they battle the Ravens (-5.5) on 'Monday Night Football.' Before locking in any Week 10 NFL picks, be sure to see the NFL parlay and betting advice from SportsLine's proven computer model. The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 10 of the 2026 NFL season on a 62-52 run on top-rated picks dating back to 2024.
Anybody following its picks at NFL betting sites could have seen strong returns. Now, the model has scoured the Week 10 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of over +2000.
You can only see the model's Week 10 NFL picks at SportsLine. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: After simulating every game 10,000 times, the model is backing the Over 40.5 in the Dolphins vs. Colts matchup, hitting in 77% of simulations at betting apps on Sunday at 1 p.m.
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