site: media | arena: betting | pageType: stories | section: | slug: week-5-2026-nfl-odds-picks-predictions-lines-spread-total-moneyline-bets | sport: betting | route: article_single.us | 6-keys: media/spln/betting/reg/free/stories ![Image 2: [object Object] Logo](https://sportshub.cbsistatic.com/i/2020/04/22/e9ceb731-8b3f-4c60-98fe-090ab66a2997/screen-shot-2020-04-22-at-11-04-56-am.png) Build a franchise, control your destiny, play like the pros Play Now This page may contain affiliate links. If you click a link and sign up, make a deposit, place a wager, or make a trade, we may earn a commission at no additional cost to you. Week 5 NFL odds, picks, predictions: Computer model backs Vikings and Bengals SportsLine's advanced model has simulated every game in the Week 5 NFL schedule 10,000 times and locked in its NFL best bets today The Week 5 NFL schedule has just one game featuring teams over .500 versus one another.
Seahawks vs. 49ers has Seattle favored by 3 points at home, per the Week 5 NFL odds, while there's a litany of matchups pitting teams without winning records against each other. Chief among them is Texans vs. Titans (+7) as both are among the four winless squads left after Tampa won on Thursday.
Others include Steelers vs. Cardinals (+5.5) and Bengals vs. Dolphins (+7.5) as Miami is, again, the biggest Sunday underdog according to the latest Week 5 NFL lines.**Visit our****Kalshi promo code****review andget a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55:** Colts vs.
Steelers has a rather slim NFL spread, considering that Indy is coming off a trip from London, while Pittsburgh is coming off a Thursday game and mini-bye. The Steelers have won five straight home games versus the Colts. Speaking of byes, this is the first slate of games with them, and without 16 games to make Week 5 NFL predictions on, you can devote more time, effort and bets on a smaller register of matchups.All of the updated Week 5 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 5 NFL picks now.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players onbetting siteson top-rated NFL picks since its inception. The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024. Anybody following its picks atNFL betting sitescould have seen strong returns.
Now, it has turned its attention to the latestWeek 5 NFL oddsand NFL betting lines and locked in betting picks for every NFL matchup. Head here to see every pick. **Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after $10 in trades**: We can tell you one of the model's strongest Week 5 NFL picks for the best betting apps is that the Vikings (-1.5, 42) cover versus the Saints in a Sunday 1 p.m. New Orleans will host, and being a home dog isn't a good thing for Saints backers.
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